期刊
CHEMICAL SCIENCE
卷 7, 期 10, 页码 6407-6412出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6sc02653b
关键词
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资金
- State Key Laboratory of Elemento-Organic Chemistry at Nankai University
- University of Pittsburgh
A photoredox-mediated Minisci C-H alkylation reaction of N-heteroarenes with alkyl boronic acids is reported. A broad range of primary and secondary alkyl groups can be efficiently incorporated into various N-heteroarenes using [Ru(bpy)(3)]Cl-2 as photocatalyst and acetoxybenziodoxole as oxidant under mild conditions. The reaction exhibits excellent substrate scope and functional group tolerance, and offers a broadly applicable method for late-stage functionalization of complex substrates. Mechanistic experiments and computational studies suggest that an intramolecularly stabilized ortho-iodobenzoyloxy radical intermediate might play a key role in this reaction system.
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