期刊
CHEMICAL SCIENCE
卷 7, 期 7, 页码 4754-4758出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6sc00807k
关键词
-
资金
- Natural Sciences and Engineering Research Council (NSERC)
- University of Ottawa
- American Chemical Society Petroleum Research Fund
- CREATE
- NSERC
Although visible light photoredox catalysis has emerged as a powerful tool for the construction of C-C bonds, common catalysts and/or their photoexcited states suffer from low redox potentials, limiting their applicability to alkyl radical generation from substrates with activated carbon-halogen bonds. Radicals derived from these activated compounds, being highly electrophilic or stabilized, do not undergo efficient addition to heteroarenes. Herein we describe the photocatalytic generation of nucleophilic alkyl radicals from unactivated bromoalkanes as part of a universal and efficient cross-coupling strategy for the direct alkylation of heteroarenes using a dimeric gold(I) photoredox catalyst, [Au-2(bis(diphenylphosphino) methane)(2)] Cl-2. The method proves to be efficient for alkylation of arenes under mild conditions in the absence of directing groups.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据