β-Arylation of oxime ethers using diaryliodonium salts through activation of inert C(sp3)-H bonds using a palladium catalyst

An efficient method of selective beta-arylation of oxime ethers was realized by using a palladium catalyst with diaryliodonium salts as the key arylation reagents. The reaction proceeded smoothly through the activation of inert C(sp(3))-H bonds to give corresponding ketones and aldehydes. This convenient procedure can be successfully applied to construct new C(sp(3))-C(sp(2)) bonds on a number of complex molecules derived from natural products and thus serves as a practical synthetic tool for direct late-stage C(sp(3))-H functionalization.