期刊
CHEMICAL SCIENCE
卷 7, 期 9, 页码 6006-6014出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6sc01851c
关键词
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资金
- National Basic Research Program of China [2013CB834502]
- NSFC/China [21434005, 91527301]
- Fundamental Research Funds for the Central Universities
- US National Institutes of Health [GM103790]
- Robert A. Welch Foundation
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM103790] Funding Source: NIH RePORTER
We report here a new approach for creating diversiform copolymer-derived self-assembly morphologies that relies on macrocycle/anion recognition in aqueous media. This approach exploits the anion binding features of a water-soluble form of the so-called 'Texas-sized' molecular box. When this tetracationic receptor is added to an aqueous solution of an amphiphilic copolymer bearing tethered carboxylate anion substituents, binding occurs to form a macrocycle/polymer complex. As the concentration of the box-like receptor increases, the relative hydrophilic fraction of the copolymer complex likewise increases. This leads to changes in the overall morphology of the self-assembled ensemble. The net result is an environmentally controllable system that mimics on a proof-of-concept level the structural evolution of organelles seen in living cells. The macrocycle/anion interactions respond in differing degrees to three key biological species, namely ATP, ADP, and AMP, which may be used as inputs to induce disassembly of these vehicles. As a result of this triggering and the nature of the morphological changes induced, the present copolymer system is capable of capturing and releasing in a controlled manner various test payloads, including hydrophobic and hydrophilic fluorophores. The copolymer displays a low inherent cytotoxicity as inferred from cell proliferation assays involving the HUVEC and HepG2 cell lines.
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