期刊
CHEMICAL SCIENCE
卷 7, 期 3, 页码 1896-1903出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5sc03591k
关键词
-
资金
- NSFC [21172063, 21472067]
- University of Jinan
We describe a unique approach for the development of an interesting type of the fluorescent probes, which can show different modes of fluorescence signals to distinct concentration ranges of a target of interest. The key points for the design of the new type of the fluorescent probes include the judicious selection of the dye platforms and the corresponding high-and low-sensitivity sites. It is known that the normal concentrations of biological thiols have significant biological functions. However, up-or down-regulated concentrations of thiols may induce several diseases. Therefore, it is highly important to monitor the changes of thiol concentrations in living systems. Based on the proposed strategy, we engineer the novel NIR fluorescent probe, CHMC-thiol, which remarkably can display a turn-on signal to the low concentration range of thiols and a ratiometric response to the high concentration range of thiols for the first time. We anticipate that the intriguing strategy formulated herein will be widely useful for the development of concentration range-dependent fluorescent probes.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据