期刊
CHEMICAL SCIENCE
卷 7, 期 7, 页码 4736-4740出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6sc00689b
关键词
-
资金
- National Natural Science Foundation of China [21372162, 21432006, 21321061]
A highly efficient catalytic asymmetric alpha-addition of isocyanides to alkylidene malonates was accomplished. The process was based on the utilization of a chiral N,N'-dioxide/Mg-II catalyst, delivering a variety of 2-alkyl-5-aminooxazoles in up to 99% yield and 96% ee under mild reaction conditions. Besides, a chiral imide and dipeptide could be easily obtained by ring-opening of the oxazole product, both of which are important structural motifs for many biologically active compounds. Based on the experimental investigations and previous work, a possible transition state model was proposed.
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