期刊
CHEMICAL SCIENCE
卷 7, 期 5, 页码 3031-3035出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5sc04471e
关键词
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资金
- University of Edinburgh
- School of Chemistry
- Framework Program 7
- Royal Society
- China Scholarship Council
- EPSRC [EP/M000842/1] Funding Source: UKRI
The reduction and reductive addition (formal hydroamination) of functionalised nitroarenes is reported using a simple and bench-stable iron(III) catalyst and silane. The reduction is chemoselective for nitro groups over an array of reactive functionalities (ketone, ester, amide, nitrile, sulfonyl and aryl halide). The high activity of this earth-abundant metal catalyst also facilitates a follow-on reaction in the reductive addition of nitroarenes to alkenes, giving efficient formal hydroamination of olefins under mild conditions. Both reactions offer significant improvements in catalytic activity and chemoselectivity and the utility of these catalysts in facilitating two challenging reactions supports an important mechanistic overlap.
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