期刊
CHEMICAL SCIENCE
卷 7, 期 1, 页码 66-71出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5sc03694a
关键词
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资金
- European Research Council, ERC [336493]
- Associazione Italiana per la Ricerca sul Cancro, AIRC [14420]
- Italian Ministry of Health [GR-2010-2317212]
- Italian Ministry of University and Research (Project of National Interest, PRIN, CTAYSY)
Here we demonstrate that we can rationally and finely control the functionality of different DNA-based nanodevices and nanoswitches using electronic inputs. To demonstrate the versatility of our approach we have used here three different model DNA-based nanoswitches triggered by heavy metals and specific DNA sequences and a copper-responsive DNAzyme. To achieve electronic-induced control of these DNA-based nanodevices we have applied different voltage potentials at the surface of an electrode chip. The applied potential promotes an electron-transfer reaction that releases from the electrode surface a molecular input that ultimately triggers the DNA-based nanodevice. The use of electronic inputs as a way to finely activate DNA-based nanodevices appears particularly promising to expand the available toolbox in the field of DNA nanotechnology and to achieve a better hierarchical control of these platforms.
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