期刊
ANNUAL REVIEW OF CHEMICAL AND BIOMOLECULAR ENGINEERING, VOL 7
卷 7, 期 -, 页码 305-326出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-chembioeng-080615-034446
关键词
nanomedicine; immunoengineering; vaccine; immunomodulation; artificial antigen presentation; biomimetic nanotechnology
资金
- Direct For Mathematical & Physical Scien
- Division Of Materials Research [GRANTS:13660380] Funding Source: National Science Foundation
- Division Of Materials Research
- Direct For Mathematical & Physical Scien [1505699] Funding Source: National Science Foundation
The immune system is an incredibly complex biological network that plays a significant role in almost all disease pathogenesis. With an increased understanding of how this vital system operates, there has been a great emphasis on leveraging, manipulating, and/or supplementing endogenous immunity to better prevent or treat different disease states. More recently, the advent of nanotechnology has ushered in a plethora of new nanoparticle-based platforms that can be used to improve existing immunomodulation modalities. As the ability to engineer at the nanoscale becomes increasingly sophisticated, nanoparticles can be finely tuned to effect the desired immune responses, leading to exciting new avenues for addressing pressing issues in public health. In this review, we give an overview of the different areas in which nanoparticle technology has been applied toward modulating the immune system and highlight the recent advances within each.
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