期刊
Science of Advanced Materials
卷 8, 期 12, 页码 2204-2215出版社
AMER SCIENTIFIC PUBLISHERS
DOI: 10.1166/sam.2016.2999
关键词
HA-Binding Peptide; Intrafibrillar Biomineralization; Amorphous Calcium Phosphate; Stabilization
资金
- National Science Foundation of China [81170986, 81171460, 81401525]
The present study aimed at determining the role of genetically engineered peptide in the process of biomimetic mineralization. The process of biomimetic mineralization is regulated by a polymer with a view to mimicking natural protein function in bone or teeth tissues. We report herein on the production of a hierarchical nanocomposite designed to emulate bone's subtle nanostructure using genetically engineered peptide for inorganics (GEPIs) via a liquid-precursor pathway. Scanning electron microscopy (SEM), transmission electron microscopy (TEM), thermogravimetric analysis and a variety of other measurements showed that the collagen scaffolds attained a good degree of intrafibrillar mineralization. The enamel hydroxyapatite binding peptide (EHABP, the selected GEPI peptide)-mediated solution was analyzed by optical density turbidity measurements. The results indicated that the solution was stabilized under EHABPs' control at least 14 days, which was sufficient to facilitate the infiltration of amorphous calcium phosphate into the interior of the collagen fibrils. Compared with poly acrylic acid, which has been traditionally applied for similar aims, it is concluded that the EHABP, a genetically engineering peptide has a stronger influence on biomineralization.
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