期刊
VIRUSES-BASEL
卷 8, 期 7, 页码 -出版社
MDPI
DOI: 10.3390/v8070180
关键词
RNA granules; stress granules; P-bodies; anti-viral host immune response; translation control
类别
资金
- Conicyt Chile through the Fondecyt Initiation Into Research Program [11140502, 11150611]
- Conicyt [DRI USA2013-0005]
- Proyecto from Iniciativa Cientifica Milenio del Ministerio de Economia, Fomento y Turismo [P09/016-F]
- Proyecto Anillo [ACT1408]
After viral infection, host cells respond by mounting an anti-viral stress response in order to create a hostile atmosphere for viral replication, leading to the shut-off of mRNA translation (protein synthesis) and the assembly of RNA granules. Two of these RNA granules have been well characterized in yeast and mammalian cells, stress granules (SGs), which are translationally silent sites of RNA triage and processing bodies (PBs), which are involved in mRNA degradation. This review discusses the role of these RNA granules in the evasion of anti-viral stress responses through virus-induced remodeling of cellular ribonucleoproteins (RNPs).
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