期刊
VIRUSES-BASEL
卷 8, 期 12, 页码 -出版社
MDPI
DOI: 10.3390/v8120322
关键词
Zika virus; chloroquine; antiviral; microcephaly; neural stem cell
类别
资金
- Conselho Nacional de Desenvolvimento e Pesquisa (CNPq)
- Fundacao de Amparo a Pesquisa do Estado do Rio de Janeiro (FAPERJ)
- Departamento de Doencas Sexualmente Transmissiveis, AIDS e Hepatites Virais do Ministerio da Saude do Brasil
- MRC [MC_PC_15102] Funding Source: UKRI
Zika virus (ZIKV) infection in utero might lead to microcephaly and other congenital defects. Since no specific therapy is available thus far, there is an urgent need for the discovery of agents capable of inhibiting its viral replication and deleterious effects. Chloroquine is widely used as an antimalarial drug, anti-inflammatory agent, and it also shows antiviral activity against several viruses. Here we show that chloroquine exhibits antiviral activity against ZIKV in Vero cells, human brain microvascular endothelial cells, human neural stem cells, and mouse neurospheres. We demonstrate that chloroquine reduces the number of ZIKV-infected cells in vitro, and inhibits virus production and cell death promoted by ZIKV infection without cytotoxic effects. In addition, chloroquine treatment partially reveres morphological changes induced by ZIKV infection in mouse neurospheres.
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