期刊
VIRUSES-BASEL
卷 8, 期 8, 页码 -出版社
MDPI AG
DOI: 10.3390/v8080229
关键词
hepatitis E virus; quasi-envelopment
类别
资金
- Pinnacle Research Award in Liver Diseases from the American Association for the Study of Liver Diseases Foundation
- National Institute of Allergy and Infectious Diseases of the National Institutes of Health [R21AI122228]
- Nationwide Children's Hospital
Hepatitis E virus (HEV), an enterically transmitted hepatotropic virus, was thought to be non-enveloped for decades. However, recent studies have revealed that the virus circulating in the patient's blood is completely cloaked in host membranes and resistant to neutralizing antibodies. The discovery of this novel enveloped form of HEV has raised a series of questions about the fundamental biology of HEV and the way this virus, which has been understudied in the past, interacts with its host. Here, we review recent advances towards understanding this phenomenon and discuss its potential impact on various aspects of the HEV life cycle and immunity.
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