期刊
VIRUSES-BASEL
卷 8, 期 6, 页码 -出版社
MDPI AG
DOI: 10.3390/v8060152
关键词
PI3K; Akt; mTOR; virus; 4EBP1; autophagy
类别
资金
- Canadian Institutes of Health Research (CIHR) [MOP-38111, MOP-56974]
- Canadian HIV Cure Enterprise Team Grant from the CIHR [HIG-133050]
- Canadian Foundation for HIV-1/AIDS Research
- International AIDS Society
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico fellowship (Brazil)
The mammalian target of rapamycin (mTOR) is a central regulator of gene expression, translation and various metabolic processes. Multiple extracellular (growth factors) and intracellular (energy status) molecular signals as well as a variety of stressors are integrated into the mTOR pathway. Viral infection is a significant stress that can activate, reduce or even suppress the mTOR signaling pathway. Consequently, viruses have evolved a plethora of different mechanisms to attack and co-opt the mTOR pathway in order to make the host cell a hospitable environment for replication. A more comprehensive knowledge of different viral interactions may provide fruitful targets for new antiviral drugs.
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