期刊
VIRUSES-BASEL
卷 8, 期 6, 页码 -出版社
MDPI
DOI: 10.3390/v8060164
关键词
Bunyaviridae; bunyavirus; nairovirus; Dera Ghazi Khan virus; Erve virus; Ganjam virus; Hughes virus; Qalyub virus; Sakhalin virus; Tunis virus; virus classification; virus taxonomy
类别
资金
- Defense Threat Reduction Agency [1881290]
- United States Department of Defense, Defense Biological Products Assurance Office
- US National Institutes of Health (NIH) [HHSN272201000040I/HHSN27200004/D04]
- Intramural Research Program of the NIH, National Library of Medicine
- Battelle Memorial Institute
- US National Institute of Allergy and Infectious Diseases (NIAID) [HHSN272200700016I]
Nairovirus, one of five bunyaviral genera, includes seven species. Genomic sequence information is limited for members of the Dera Ghazi Khan, Hughes, Qalyub, Sakhalin, and Thiafora nairovirus species. We used next-generation sequencing and historical virus-culture samples to determine 14 complete and nine coding-complete nairoviral genome sequences to further characterize these species. Previously unsequenced viruses include Abu Mina, Clo Mor, Great Saltee, Hughes, Raza, Sakhalin, Soldado, and Tillamook viruses. In addition, we present genomic sequence information on additional isolates of previously sequenced Avalon, Dugbe, Sapphire II, and Zirqa viruses. Finally, we identify Tunis virus, previously thought to be a phlebovirus, as an isolate of Abu Hammad virus. Phylogenetic analyses indicate the need for reassignment of Sapphire II virus to Dera Ghazi Khan nairovirus and reassignment of Hazara, Tofla, and Nairobi sheep disease viruses to novel species. We also propose new species for the Kasokero group (Kasokero, Leopards Hill, Yogue viruses), the Ketarah group (Gossas, Issyk-kul, Keterah/soft tick viruses) and the Burana group (Wenzhou tick virus, Huangpi tick virus 1, Tacheng tick virus 1). Our analyses emphasize the sister relationship of nairoviruses and arenaviruses, and indicate that several nairo-like viruses (Shayang spider virus 1, Xinzhou spider virus, Sanxia water strider virus 1, South Bay virus, Wuhan millipede virus 2) require establishment of novel genera in a larger nairovirus-arenavirus supergroup.
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