期刊
CLINICAL INFECTIOUS DISEASES
卷 61, 期 -, 页码 S290-S301出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/cid/civ737
关键词
Salmonella; nontyphoidal; Typhi; incidence; Kenya
资金
- Wellcome Trust through core support to the KEMRI-Wellcome Trust Research Programme and training and clinical research fellowship [103951, 053439, 083579, 091758, 098532]
- Gavi, the Vaccine Alliance, through support for bacteremia surveillance within a study of pneumococcal vaccine
- Bill & Melinda Gates Foundation [OPP1125993]
- Medical Research Council [MR/M007367/1] Funding Source: researchfish
- MRC [MR/M007367/1] Funding Source: UKRI
- Bill and Melinda Gates Foundation [OPP1125993] Funding Source: Bill and Melinda Gates Foundation
Background. Invasive salmonelloses are a major cause of morbidity and mortality in Africa, but the incidence and case fatality of each disease vary markedly by region. We aimed to describe the incidence, clinical characteristics, and antimicrobial susceptibility patterns of invasive salmonelloses among children and adults in Kilifi, Kenya. Methods. We analyzed integrated clinical and laboratory records for patients presenting to the Kilifi County Hospital between 1998 and 2014. We calculated incidence, and summarized clinical features and multidrug resistance. Results. Nontyphoidal Salmonella (NTS) accounted for 10.8% and 5.8% of bacteremia cases in children and adults, respectively, while Salmonella Typhi accounted for 0.5% and 2.1%, respectively. Among 351 NTS isolates serotyped, 160 (45.6%) were Salmonella Enteritidis and 152 (43.3%) were Salmonella Typhimurium. The incidence of NTS in children aged <5 years was 36.6 per 100 000 person-years, being highest in infants aged <7 days (174/100 000 person-years). The overall incidence of NTS in children varied markedly by location and declined significantly during the study period; the pattern of dominance of the NTS serotypes also shifted from Salmonella Enteritidis to Salmonella Typhimurium. Risk factors for invasive NTS disease were human immunodeficiency virus infection, malaria, and malnutrition; the case fatality ratio was 22.1% (71/321) in children aged <5 years and 36.7% (11/30) in adults. Multidrug resistance was present in 23.9% (84/351) of NTS isolates and 46.2% (12/26) of Salmonella Typhi isolates. Conclusions. In Kilifi, the incidence of invasive NTS was high, especially among newborn infants, but typhoid fever was uncommon. NTS remains an important cause of bacteremia in children <5 years of age.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据