期刊
WOUND REPAIR AND REGENERATION
卷 24, 期 2, 页码 204-214出版社
WILEY
DOI: 10.1111/wrr.12415
关键词
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资金
- NIGMS NIH HHS [R01 GM063569, R01 GM069668] Funding Source: Medline
Pericytes have generally been considered in the context of stabilizing vessels, ensuring the blood barriers, and regulating the flow through capillaries. However, new reports suggest that pericytes may function at critical times to either drive healing with minimal scarring or, perversely, contribute to fibrosis and ongoing scar formation. Beneficially, pericytes probably drive much of the vascular involution that occurs during the transition from the regenerative to the resolution phases of healing. Pathologically, pericytes can assume a fibrotic phenotype and promote scarring. This perspective will discuss pericyte involvement in wound repair and the relationship pericytes form with the parenchymal cells of the skin. We will further evaluate the role pericytes may have in disease progression in relation to chronic wounds and fibrosis.
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