期刊
WORLD JOURNAL OF GASTROENTEROLOGY
卷 22, 期 28, 页码 6434-6443出版社
BAISHIDENG PUBLISHING GROUP INC
DOI: 10.3748/wjg.v22.i28.6434
关键词
Guanylate-binding proteins; Colorectal carcinoma; Inflammatory bowel diseases; Interferon
资金
- German Research Foundation [DFG-KFO257, SFB796, DFG-BR5196, FOR2438]
- Interdisciplinary Center for Clinical Research (IZKF) of the Clinical Center Erlangen
Guanylate-binding proteins (GBPs) are interferon-stimulated factors involved in the defense against cellular pathogens and inflammation. These proteins, particularly GBP-1, the most prominent member of the family, have been established as reliable markers of interferon-gamma-activated cells in various diseases, including colorectal carcinoma (CRC) and inflammatory bowel diseases (IBDs). In CRC, GBP-1 expression is associated with a Th1-dominated angiostatic micromilieu and is correlated with a better outcome. Inhibition of tumor growth by GBP-1 is the result of its strong anti-angiogenic activity as well as its direct anti-tumorigenic effect on tumor cells. In IBD, GBP-1 mediates the anti-proliferative effects of interferon-gamma on intestinal epithelial cells. In addition, it plays a protective role on the mucosa by preventing cell apoptosis, by inhibiting angiogenesis and by regulating the T-cell receptor signaling. These functions rely to a large extent on the ability of GBP-1 to interact with and remodel the actin cytoskeleton.
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