期刊
WORLD JOURNAL OF GASTROENTEROLOGY
卷 22, 期 11, 页码 3127-3149出版社
BAISHIDENG PUBLISHING GROUP INC
DOI: 10.3748/wjg.v22.i11.3127
关键词
Colonic neoplasms; Rectal neoplasms; Neoplasm metastasis; Antineoplastic agents; FOLFOX protocol; irinotecan; 5-flurouracil, and leucovorin protocol; Radiofrequency ablation; Microwave ablation; Chemoembolization; Therapeutic; Immunotherapy
Colorectal cancer metastasizes predictably, with liver predominance in most cases. Because liver involvement has been shown to be a major determinant of survival in this population, liver-directed therapies are increasingly considered even in cases where there is (limited) extrahepatic disease. Unfortunately, these patients carry a known risk of recurrence in the liver regardless of initial therapy choice. Therefore, there is a demand for minimally invasive, non-surgical, personalized cancer treatments to preserve quality of life in the induction, consolidation, and maintenance phases of cancer therapy. This report aims to review evidence-based conceptual, pharma cological, and technological paradigm shifts in parenteral and percutaneous treatment strategies as well as forthcoming evidence regarding next-generation systemic, locoregional, and local treatment approaches for this patient population.
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