期刊
WORLD JOURNAL OF GASTROENTEROLOGY
卷 22, 期 17, 页码 4287-4296出版社
BAISHIDENG PUBLISHING GROUP INC
DOI: 10.3748/wjg.v22.i17.4287
关键词
Hepatitis B virus infection; precore/core mutations; hepatocellular carcinoma; HBeAg serostatus; disease severity
资金
- National Research Foundation grant of Ministry of Science, ICT and Future Planning, South Korea [NRF-2015R1C1A1A02037267]
- Korea Health Technology R&D Project through the Korea Health Industry Development Institute, the Ministry of Health and Welfare, South Korea [HI14C0955]
Despite the availability of an effective vaccine, hepatitis B virus (HBV) infection remains a major health problem, with more than 350 million chronically infected people worldwide and over 1 million annual deaths due to cirrhosis and liver cancer. HBV mutations are primarily generated due both to a lack of proofreading capacity by HBV polymerase and to host immune pressure, which is a very important factor for predicting disease progression and therapeutic outcomes. Several types of HBV precore/core (preC/C) mutations have been described to date. The host immune response against T cells drives mutation in the preC/C region. Specifically, preC/C mutations in the MHC class. restricted region are more common than in other regions and are significantly related to hepatocellular carcinoma. Certain mutations, including preC G1896A, are also significantly related to HBeAg-negative chronic infection. This review article mainly focuses on the HBV preC/C mutations that are related to disease severity and on the HBeAg serostatus of chronically infected patients.
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