期刊
CLINICAL IMPLANT DENTISTRY AND RELATED RESEARCH
卷 18, 期 5, 页码 906-916出版社
WILEY
DOI: 10.1111/cid.12369
关键词
abutments; titanium; zirconia; epithelial attachment
资金
- Aichi Gakuin University [24593137]
- Ministry of Education, Culture, Sports, Science, and Technology of Japan
- Japan Society for the Promotion of Science [C-24592960]
- Grants-in-Aid for Scientific Research [15K11402] Funding Source: KAKEN
Background: Few studies have examined epithelial attachment to zirconia and the proliferative ability of epithelial cells on zirconia surfaces. Purpose: To evaluate the adhesion properties of zirconia materials for epithelial cell attachment and compare this with titanium and alumina. Materials and Methods: Human oral epithelial cells were cultured on smooth-surfaced specimens of commercially pure titanium (cpTi), ceria-stabilized zirconia/alumina nano-composite (P-NANOZR), yttria-stabilized zirconia (Cercon), and alumina oxide (inCoris AL). The cell morphology, the cell viability and mRNA of integrin beta(4), laminin gamma(2), catenin delta(2), and E-cadherin were evaluated by SEM, Cell-Counting Kit-8, and real-time PCR, respectively. Results: Morphology of cells attached to specimens was similar among all groups. The viable cell numbers on Cercon and inCoris AL after 24 hours culture were significantly higher than for cpTi. Integrin beta(4), laminin gamma(2), and catenin delta(2) mRNA expression was not different among all groups. However, at 3 and 24 hours after incubation, E-cadherin mRNA expression in the P-NANOZR group was significantly higher than for cpTi. Conclusion: Zirconia may support binding of epithelial cells through hemidesmosomes comparable with titanium. Furthermore, P-NANOZR may impart resistance to exogenous stimuli through strong intercellular contacts with peri-implant mucosal cells when used as an abutment and implant superstructure.
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