4.7 Article

The Milieu Interieur study An integrative approach for study of human immunological variance

期刊

CLINICAL IMMUNOLOGY
卷 157, 期 2, 页码 277-293

出版社

ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.clim.2014.12.004

关键词

Healthy donor; Cohort design; Immune phenotypes; Baseline serologic data; Metabolic syndrome; CMV

资金

  1. French governments Invest in the Future program [10-LABX-69-01]

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The Milieu Interieur Consortium has established a 1000-person healthy population-based study (stratified according to sex and age), creating an unparalleled opportunity for assessing the determinants of human immunologic variance. Herein, we define the criteria utilized for participant enrollment, and highlight the key data that were collected for correlative studies. In this report, we analyzed biological correlates of sex, age, smoking-habits, metabolic score and CMV infection. We characterized and identified unique risk factors among healthy donors, as compared to studies that have focused on the general population or disease cohorts. Finally, we highlight sex-bias in the thresholds used for metabolic score determination and recommend a deeper examination of current guidelines. In sum, our clinical design, standardized sample collection strategies, and epidemiological data analyses have established the foundation for defining variability within human immune responses. (C) 2014 The Authors. Published by Elsevier Inc.

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