期刊
VISION RESEARCH
卷 127, 期 -, 页码 74-83出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.visres.2016.07.006
关键词
Higher visual areas; Random dot kinematograms; Touchscreen chamber; Psychophysics; Global motion processing
资金
- Whitehall Foundation
- Klingenstein Foundation
- UNC-Chapel Hill
- Simons Foundation [SCGB 325407SS]
- NSF [1450824]
- NIH [R01EY024294, NRSA F31HD084174, T32NS007431]
- Autism Speaks
- HHMI Graduate Training Program in Translational Medicine at UNC
- Burroughs Wellcome Career Award at the Scientific Interface and NIH training grant [T32HD40127]
- Carolina Institute for Developmental Disabilities [NIH U54HD055741]
- Div Of Biological Infrastructure
- Direct For Biological Sciences [1450824] Funding Source: National Science Foundation
Global motion perception is a function of higher, or extrastriate, visual system circuitry. These circuits can be engaged in visually driven navigation, a behavior at which mice are adept. However, the properties of global motion perception in mice are unclear. Therefore, we developed a touchscreen-based, two-alternative forced choice (2AFC) task to explore global motion detection in mice using random dot kinematograms (RDK). Performance data was used to compute coherence thresholds for global motion perception. The touchscreen-based task allowed for parallel training and testing with multiple chambers and minimal experimenter intervention with mice performing hundreds of trials per session. Parameters of the random dot kinematograms, including dot size, lifetime, and speed, were tested. Mice teamed to discriminate kinematograms whose median motion direction differed by 90 degrees in 7-24 days after a 10-14 day pre-training period. The average coherence threshold (measured at 70% correct) in mice for this task was 22 +/- 5%, with a dot diameter of 3.88 mm and speed of 58.2 mm/s. Our results confirm the ability of mice to perform global motion discriminations, and the touchscreen assay provides a flexible, automated, and relatively high throughput method with which to probe complex visual function in mice. (C) 2016 The Authors. Published by Elsevier Ltd.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据