期刊
VIRUS RESEARCH
卷 213, 期 -, 页码 214-218出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.virusres.2015.12.008
关键词
Pseudorabies virus; gE; ERK1/2; Bim
类别
资金
- Fundacao para a Ciencia e Tecnologia (FCT) [SFRH/BD/70289/2010]
- F.W.O.-Vlaanderen [G.0835.09]
- Concerted Research Action of the Special Research Fund of Ghent University [01G01311]
- Fundação para a Ciência e a Tecnologia [SFRH/BD/70289/2010] Funding Source: FCT
ERK1/2 (Extracellular signal Regulated Kinase 1/2) signaling is a key cellular signaling axis controlling many cellular events, including cell survival. Activation of ERK 1/2 may trigger an anti-apoptotic response, and different viruses have been shown to benefit from this process. We have described recently that the viral glycoprotein gE mediates pseudorabies virus (PRV)-induced activation of ERK 1/2 in T lymphocytes. In the present study, we report that PRV gE-mediated ERK 1/2 phosphorylation also occurs in epithelial cells and that in these cells, gE-mediated ERK 1/2 signaling is associated with degradation of the pro-apoptotic protein Bim. Our results for the first time link the viral glycoprotein gE, an important alphaherpesvirus virulence factor, with the apoptotic signaling pathway. (C) 2015 Elsevier B.V. All rights reserved.
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