期刊
VIRUS GENES
卷 52, 期 5, 页码 716-721出版社
SPRINGER
DOI: 10.1007/s11262-016-1355-5
关键词
Alphaviruses; Chikungunya virus; Ubiquitin proteasome system (UPS); Calpain; m-Calpain
资金
- INSPIRE Faculty Award from Dept. of Science and Technology (Govt. of India), New Delhi
Replication of many viruses is dependent on the ubiquitin proteasome system. The present study demonstrates that Chikungunya virus replication increases proteasome activity and induces unfolded protein response (UPR) in cultured cells. Further, it was seen that the virus replication was dependent on the activities of proteasomes and m-calpain. Proteasome inhibition induced accumulation of polyubiquitinated proteins and earlier visualization of UPR.
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