期刊
VIROLOGY
卷 494, 期 -, 页码 190-197出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.virol.2016.04.019
关键词
Avian influenza; Highly pathogenic avian influenza; Glade 2.3.4.4; Infectivity; Pathobiology; Poultry; Wild waterfowl; Transmission
类别
资金
- USDA/ARS CRIS Project [6040-320000-63]
- CRIP (Center of Research in Influenza Pathogenesis) an NIAID - Center of Excellence in Influenza Research and Surveillance (CEIRS) [HHSN272201400008C]
In 2014-2015, the U.S. experienced an unprecedented outbreak of Eurasian Glade 2.3.4.4 H5 highly pathogenic avian influenza (HPAI) virus, initially affecting mainly wild birds and few backyard and commercial poultry premises. To better model the outbreak, the pathogenesis and transmission dynamics of representative Eurasian H5N8 and reassortant H5N2 Glade 2.3.4.4 HPAI viruses detected early in the North American outbreak were investigated in chickens. High mean chicken infectious doses and lack of seroconversion in survivors indicated the viruses were poorly chicken adapted. Pathobiological features were consistent with HPAI virus infection, although the delayed appearance of lesions, longer mean death times, and reduced replication in endothelial cells differed from features of most other Eurasian H5N1 HPAI viruses. Although these initial U.S. H5 HPAI viruses had reduced adaptation and transmissibility in chickens, multi-generational passage in poultry could generate poultry adapted viruses with higher infectivity and transmissibility. (C) 2016 Published by Elsevier Inc.
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