期刊
VIROLOGY
卷 499, 期 -, 页码 219-229出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.virol.2016.09.016
关键词
Cyanophage; Myoviruses; Auxiliary; Metabolic; Genes; Selection; Genome; Evolution; Marine
类别
资金
- National Science Foundation [OCE-1029684, OCE-1332782, OCE-1031783, OCE-1332740]
- RWU Foundation
- Directorate For Geosciences [1332740] Funding Source: National Science Foundation
- Division Of Ocean Sciences [1332740] Funding Source: National Science Foundation
- Division Of Ocean Sciences
- Directorate For Geosciences [1332782] Funding Source: National Science Foundation
Viruses of marine cyanobacteria frequently contain auxiliary metabolic genes (AMGs) that augment host metabolism during infection, but little is known about their adaptive significance. We analyzed the distribution and genomic context of 33 AMGs across 60 cyanomyovirus genomes. Similarity in AMG content among cyanomyoviruses was only weakly correlated with phylogenetic relatedness; however, AMG content was generally conserved within the same operational taxonomic unit (OTU). A virus' AMG repertoire was also correlated with its isolation host and environment (coastal versus open ocean). A new analytical method based on shared co-linear blocks revealed that variation in the genomic location of an AMG was negatively correlated with its frequency across the genomes. We propose that rare AMGs are more frequently gained or lost as a result of fluctuating selection pressures, whereas common AMGs are associated with stable selection pressures. Finally, we describe a unique cyanomyovirus (S-CAM7) that lacks many AMGs including the photosynthesis gene psbA. (C) 2016 Elsevier Inc. All rights reserved.
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