期刊
VIROLOGY
卷 487, 期 -, 页码 1-10出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.virol.2015.09.019
关键词
Virus; Neurotropic; Sciatic nerve; Interferon; Barrier; Poliovirus; Reovirus; Yellow fever virus 17D
类别
资金
- U.S. Public Health Service from the National Institute of Allergy and Infectious Diseases [AI074668, AI038296]
- Burroughs Wellcome Foundation Investigators in the Pathogenesis of Infectious Diseases award
- Elizabeth B. Lamb Center for Pediatric Research
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI074668, R01AI038296, R37AI038296] Funding Source: NIH RePORTER
Neurotropic viruses initiate infection in peripheral tissues prior to entry into the central nervous system (CNS). However, mechanisms of dissemination are not completely understood. We used genetically marked viruses to compare dissemination of poliovirus, yellow fever virus 17D (YFV-17D), and reovirus type 3 Dearing in mice from a hind limb intramuscular inoculation site to the sciatic nerve, spinal cord, and brain. While YFV-17D likely entered the CNS via blood, poliovirus and reovirus likely entered the CNS by transport through the sciatic nerve to the spinal cord. We found that dissemination was inefficient in adult immune-competent mice for all three viruses, particularly reovirus. Dissemination of all viruses was more efficient in immune-deficient mice. Although poliovirus and reovirus both accessed the CNS by transit through the sciatic nerve, stimulation of neuronal transport by muscle damage enhanced dissemination only of poliovirus. Our results suggest that these viruses access the CNS using different pathways. (C) 2015 Elsevier Inc. All rights reserved.
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