期刊
VETERINARNI MEDICINA
卷 61, 期 1, 页码 35-50出版社
CZECH ACADEMY AGRICULTURAL SCIENCES
DOI: 10.17221/8681-VETMED
关键词
metals; fish; antioxidant defence; pesticides
资金
- Internal Grant Agency of the University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic [22 /2013/FVHE]
The aim of the present study was to investigate the impact of copper-based pesticides (at concentrations of copper of 20, 30, 40 and 70 mu g/l) on one-year-old common carp (Cyprinus carpio L.) during 28 days of exposure. Abnormal behaviour was observed in fish exposed to 70 mu g/l from Day 14. Histological alterations were noticed only in liver in the groups exposed to 40 and 70 mu g/l. Significant changes (P < 0.05) in almost all haematological indices were found, especially in the group exposed to the highest concentration of copper (70 mu g/l). Biochemical analysis revealed various significant (P < 0.05) differences among the tested groups. Significant differences in copper tissue concentration (P < 0.05) among groups were found in liver, gills and kidney. Among antioxidative enzymes, significant changes were revealed mainly in catalase and glutathione-S-transferase activity (P < 0.05). In gills, metallothionein content increased significantly (P < 0.05) in the group exposed to the highest copper concentration (70 mu g/l) compared with the other tested groups, including the control. A significant (P < 0.05) change in total glutathione content was recorded in liver and gills, although the reduced/oxidised ratio was not affected. Oxidative damage to lipids increased significantly (P < 0.05) with increasing copper concentration in liver and kidney. The results demonstrate the deleterious influence of copper on common carp even at low, environmentally relevant concentrations.
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