期刊
VASCULAR PHARMACOLOGY
卷 86, 期 -, 页码 53-63出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.vph.2016.05.009
关键词
Cardiac pericyte; Heart; Ischemic heart disease; Perivascular cell; Vascular stem cell; Adventitial progenitors; Myocardial infarction
资金
- British Heart Foundation UK [PG/15/32/31398]
- manufacture scale up of human pericyte progenitor cells for regenerative medicine, MRC Translational Stem Cell Research Grant [MR/J015350/1]
- Bristol Biomedical Research Unit in Cardiovascular Disease (lead for Regenerative Medicine work package), National Institute Health Research Biomedical Research Unit (NIHR BRU)
- BHF Centre of Regenerative Medicine
- MRC [MR/N027086/1] Funding Source: UKRI
- British Heart Foundation [PG/15/32/31398, PG/10/81/28606] Funding Source: researchfish
- Medical Research Council [MR/N027086/1] Funding Source: researchfish
Microvascular pericytes and the more recently discovered adventitial pericyte-like progenitor cells are a subpopulation of vascular stem cells closely associated with small and large blood vessels respectively. These populations of perivascular cells are remarkably abundant in the heart. Pericytes control important physiological processes such as angiogenesis, blood flow and vascular permeability. In the heart, this pleiotropic activity makes pericytes extremely interesting for applications in regenerative medicine. On the other hand, dysfunction of pericytes could participate in the pathogenesis of cardiovascular disease, such as arterial hypertension, fibro-calcific cardiovascular remodeling, myocardial edema and post-ischemic coronary no-reflow. On a therapeutic standpoint, preclinical studies in small animal models of myocardial infarction have demonstrated the healing potential of pericytes transplantation, which has been ascribed to direct vascular incorporation and paracrine pro-angiogenic and anti-apoptotic activities. These promising findings open the door to the clinical use of pericytes for the treatment of cardiovascular diseases. (C) 2016 Elsevier Inc All rights reserved.
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