期刊
VACCINE
卷 34, 期 38, 页码 4565-4571出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2016.07.031
关键词
Nasopharyngeal pneumococcal carriage; Colonization; Pneumococcal serotype; Pneumococcal conjugate vaccine
资金
- ALF
- Stockholm County Council
- Swedish Research Council
- Swedish Foundation for Strategic Research
- Knut and Alice Wallenberg Foundation
- Foundation Samariten
- Sachs' Children and Youth Hospital
Objective: To evaluate the carriage prevalence, serotype distribution, and antibiotic resistance for pneumococcal carriage isolates collected 4-8 years after introduction of pneumococcal conjugate vaccines (PCVs) in Stockholm, Sweden, and to identify risk factors for carriage and calculate the invasive disease potential for emerging serotypes. Methods: Nasopharyngeal aspirates were collected from 3024 children aged 0-<5 years at regular visits at 23 Child Health Centers in Stockholm County in 2011-2015, and from 787 parents in 2014-2015. The invasive disease potential was calculated for serotypes using invasive disease isolates from 824 patients of all ages identified in the Stockholm County during the same time period as the carriage isolates. Results: A total carriage prevalence of 30% did not change during the study period. Non-vaccine types (NVT) dominated (94% by 2015) and the most common serotypes in descending order were 11A, 23B, 35F and 21. Risk factors for carriage were: age >= 3 months -<3 years, having siblings, attending day-care and having travelled abroad the last 3 months. Antibiotic resistance remained low. The invasive disease potential was high for NVT 8, 9N, 12F, and 22F, while low for a majority of emerging NVTs in carriage. Conclusion: The carriage prevalence remained the same 4-8 years after vaccine introduction, but serotype replacement became almost complete. A majority of emerging NVTs in carriage showed a low invasive disease potential. Carriage studies are an important complement to invasive disease surveillance to understand the full effect of PCV vaccine programs. (C) 2016 The Authors. Published by Elsevier Ltd.
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