期刊
VACCINE
卷 34, 期 20, 页码 2312-2320出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2016.03.066
关键词
13-Valent pneumococcal conjugate vaccination; Indigenous children; Chronic malnutrition; Saliva; Venezuela
资金
- Pfizer Venezuela
- Fundacion para la Investigacion en Micobacterias (FUNDAIM)
- Caracas
- Venezuela
- 'Integrated Microsystems for Biosensing' [3E-01, FES0901:FES HTSM]
- project of NanoNextNL
- micro and nanotechnology consortium of the Government of the Netherlands
Objective: To determine the impact of pre-vaccination nutritional status on vaccine responses in Venezuelan Warao Amerindian children vaccinated with the 13-valent pneumococcal conjugate vaccine (PCV13) and to investigate whether saliva can be used as read-out for these vaccine responses. Methods: A cross-sectional cohort of 504 Venezuelan Warao children aged 6 weeks - 59 months residing in nine geographically isolated Warao communities were vaccinated with a primary series of PCV13 according to Centers for Disease Control and Prevention (CDC)-recommended age-related schedules. Post-vaccination antibody concentrations in serum and saliva of 411 children were measured by multiplex immunoassay. The influence of malnutrition present upon vaccination on post-vaccination antibody levels was assessed by univariate and multivariable generalized estimating equations linear regression analysis. Results: In both stunted (38%) and non-stunted (62%) children, salivary antibody concentrations correlated well with serum levels for all serotypes with coefficients varying from 0.61 for serotype 3-0.80 for serotypes 5, 6A and 23F (all p < 0.01). Surprisingly, higher serum and salivary antibody levels were observed with increasing levels of stunting in children for all serotypes. This was statistically significant for 5/13 and 11/13 serotype-specific serum and saliva IgG concentrations respectively. Conclusion: Stunted Amerindian children showed generally higher antibody concentrations than well nourished children following PCV13 vaccination, indicating that chronic malnutrition influences vaccine response. Saliva samples might be useful to monitor serotype-specific antibody levels induced by PCV vaccination. This would greatly facilitate studies of vaccine efficacy in rural settings, since participant resistance generally hampers blood drawing. The study was registered in a primary registry of the World Health Organization with identifier number RPCEC00000158. (C) 2016 Elsevier Ltd. All rights reserved.
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