期刊
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
卷 34, 期 5, 页码 -出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.urolonc.2015.11.026
关键词
Clear-cell renal cell carcinoma; CCL2; Prognostic biomarker; Recurrence-free survival; Nomogram
资金
- National Natural Science Foundation of China, China [31100629, 31270863, 81372755, 81471621, 81472227, 81402082, 81402085]
- Program for New Century Excellent Talents in University [NCET-13-0146]
- Shanghai Rising-Star Program [13QA1400300]
Purpose: Chemokine (C-C motif) ligand 2 (CCL2) is known to recruit monocytes and macrophages to sites of inflammation. Recent studies suggest CCL2 is overexpressed in multiple cancer types and may play a role in the tumor progression. The aim of this study was to assess the association between CCL2 expression and the risk of recurrence after surgery in patients with clear-cell renal cell carcinoma (ccRCC). Methods: This study included 268 ccRCC patients who underwent nephrectomy at a single institute between 2001 and 2004. Clinicopathologic variables and recurrence-free survival (RFS) were recorded. CCL2 expression levels were evaluated by immunohistochemical staining in tumor tissues. Kaplan-Meier method was applied to compare survival curves. Cox regression models were fitted to analyze the effect of prognostic factors on recurrence-free survival (RFS). Harrell's concordance index was calculated to assess predictive accuracy. Results: High CCL2 expression was associated with a greater risk of recurrence in ccRCC patients (P < 0.001). Multivariate analysis confirmed that CCL2 expression was an independent prognostic factor for RFS (P = 0.045). The predictive accuracy of the Leibovich prognostic score was improved when CCL2 expression was added (0.76 vs. 0.71, P < 0.001). Notably, the improvement in prediction was more pronounced in patients with low-risk disease. A nomogram integrating CCL2 expression and pathologic factors was then constructed, which predicted 5- and 10-year RFS well for ccRCC patients. Conclusions: High chemokine CCL2 expression is an independent predictor of recurrence in ccRCC patients. Evaluation of CCL2 could help guide postsurgical management for ccRCC patients. (C) 2016 Elsevier Inc. All rights reserved.
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