期刊
ULTRASOUND IN MEDICINE AND BIOLOGY
卷 42, 期 2, 页码 624-630出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.ultrasmedbio.2015.10.010
关键词
Microbubble; Mean size diameter; Particle counting; Tunable Resistive Pulse Sensing (TRPS)
资金
- Agence Nationale de la Recherche
- Medicen, Competitivity pole of Ile de France Region [ANR-11-BSV5-0026]
- Agence Nationale de la Recherche (ANR) [ANR-11-BSV5-0026] Funding Source: Agence Nationale de la Recherche (ANR)
Microbubbles are polydisperse microparticles. Their size distribution cannot be accurately measured from the current methods used, such as optical microscopy, electrical sensing or light scattering. Indeed, these techniques present some limitations when applied to microbubbles, which prompted us to investigate the use of an alternative technique: tunable resistive pulse sensing (TRPS). This technique is based on the principle of the Coulter counter with the advantage of being more flexible compared to other methods using this principle, since the flow rate, the potential difference and the pore size can be modulated. The main limitation of TRPS is that more than one size of nanopore membrane is required to obtain the full size distribution of polydisperse microparticles. To evaluate this technique, the concentration and the size distribution of positively charged microbubbles were studied using TRPS and compared to data obtained using optical microscopy. We describe herein the parameters required for the accurate measurement of microbubble concentration and size distribution by TRPS and present a statistical comparison of the data obtained by TRPS and optical microscopy. (C) 2016 World Federation for Ultrasound in Medicine & Biology.
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