期刊
ULTRASOUND IN MEDICINE AND BIOLOGY
卷 42, 期 5, 页码 1130-1137出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.ultrasmedbio.2016.01.006
关键词
Ultrasound; Stroke; Intima-media thickness; Echogenicity; Carotid artery
资金
- NIHR Exeter Clinical Research Facility
The grey-scale median of the common carotid artery intima-media complex (IM-GSM) characterizes arterial wall composition, and a low IM-GSM is associated with increased cardiovascular mortality in the elderly. We aimed to determine differences in the IM-GSM between a cohort with cerebrovascular disease and a healthy cohort. Eighty-two healthy individuals (control group: 63.2 +/- 8.7 y) and 96 patients with either stroke or transient ischemic attacks (CRVD group: 68.6 +/- 9.8 y) were studied. Common carotid artery intima-media thickness and IM-GSM obtained by ultrasound were analyzed using semi-automated edge-detection software. The IM-GSM was significantly lower in the CRVD group than in the control group (106 +/- 24 vs. 124 +/- 27 au, p < 0.001). The IM-GSM was similar for the infarct and non-infarct sides in CRVD. In the pooled cohort of all participants, the lower the quartile of IM-GSM, the greater were the carotid artery intima-media thickness and carotid artery remodeling. These results suggest the presence of an altered atherosclerotic phenotype in the intima-media complex of CRVD patients that can be detected by ultrasound. (C) 2016 World Federation for Ultrasound in Medicine & Biology.
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