期刊
ULTRASOUND IN MEDICINE AND BIOLOGY
卷 42, 期 5, 页码 1084-1089出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.ultrasmedbio.2015.12.014
关键词
Acute levodopa challenge test; Muscle rigidity; Parkinson's disease; Speckle tracking; Ultrasound strain elastography
资金
- Capital Research Grant for Clinical Application (China) [Z121107001012140]
To evaluate the feasibility of ultrasound strain elastography in assessing the response of muscle stiffness to the acute levodopa test, we prospectively performed strain elastography on the biceps brachii muscle (BBM) of 18 patients to diagnose Parkinson's disease. BBM and subcutaneous tissue strains (deformations) were produced by external compression with an ultrasound transducer and estimated using 2-D speckle tracking. We used the strain ratio (SR 5 BBM strain/reference strain) to assess BBM stiffness. The rate of increase in SR [rate 5 (SR after levodopa-SR before levodopa)/SR before levodopa] was used to assess the muscle stiffness response to levodopa. SR significantly increased after levodopa administration in 11 patients with Parkinson's disease (p = 0.02), whereas it did not in 7 patients with parkinsonian syndrome (from non-Parkinson's causes) (p = 0.14). The area under the receiver operating characteristic curve for the rate of increase in SR in determining Parkinson's disease was 0.96. The rate of increase in SR seems to be feasible in evaluating the effect of levodopa on muscle stiffness in the diagnosis of Parkinson's disease. (C) 2016 World Federation for Ultrasound in Medicine & Biology.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据