期刊
ULTRASONICS SONOCHEMISTRY
卷 28, 期 -, 页码 161-168出版社
ELSEVIER
DOI: 10.1016/j.ultsonch.2015.07.013
关键词
Bleomycin; Disulfonated aluminum phthalocyanine; Sonodynamic therapy; Ultrasound
Sonodynamic therapy (SDT), or ultrasound combined with sonosensitization, is a promising approach because it is noninvasive and penetrates deeper than light does in photodynamic therapy. We examined whether bleomycin (BLM) could improve the efficacy of SOT. We performed an in vitro study using Colon-26 cells, which are derived from mouse colon cancer. SDT with BLM was significantly more cytotoxic than SDT alone both in vitro and in vivo. We also observed an ultrasound intensity-dependent cytotoxic effect of SDT with BLM. These findings suggest that SOT with BLM might provide a novel noninvasive treatment for deep-seated tumors. (C) 2015 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据