期刊
TUMOR BIOLOGY
卷 37, 期 7, 页码 9951-9958出版社
SAGE PUBLICATIONS LTD
DOI: 10.1007/s13277-016-4869-5
关键词
STMN1; Endometrial cancer; MMP2; MMP9; Gelatin zymography
类别
资金
- National Natural Science Foundation of China [81172476, 81272885, 81472427]
- Science and Technology Commission of Shanghai Municipality [13JC1404501]
- Doctoral Fund of Ministry of Education of China [20120073110090]
Overexpression of stathmin (STMN1) is closely linked to tumor metastases and poor prognosis in endometrial carcinoma (EC). However, the underlying mechanism is little known. In the present study, we investigated the expression of STMN1 in EC. Subsequently, we assessed the role of STMN1 in EC cell proliferation and migration. Our data show that STMN1 is upregulated in EC, and elevated expression of STMN1 is correlated positively with tumor stage and lymph node metastasis. In vitro, forced expression of STMN1 promoted cell invasion and migration. In contrast, knockdown of STMN1 inhibited cell aggressive behaviors. Moreover, the expression and the activity changes of matrix metalloproteinases (MMP)-2/9 were observed in EC cells after the cells being silenced or overexpression of STMN1. In conclusion, STMN1 is an oncogene and it enhances the growth and invasion of EC possibly by mediating the secretion and activation of MMP2 and MMP9 protein.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据