期刊
CLINICAL CANCER RESEARCH
卷 21, 期 8, 页码 1877-1887出版社
AMER ASSOC CANCER RESEARCH
DOI: 10.1158/1078-0432.CCR-14-1748
关键词
-
类别
资金
- Swedish Cancer Society [CAN 2011/497]
- Swedish Research Council [K2012-54X-22027-01-3]
- Faculty of Medicine at Lund University
- Unit of Nursing Research at Malmo University
- Faculty of Health and Society at Malmo University
- South Swedish Health Care Region (Region Skane ALF)
- Lund Hospital Fund
- Swedish Breast Cancer Group (BRO)
- Mrs. Berta Kamprad Foundation
- Crafoord Foundation
- Gunnar Nilsson Foundation
- King Gustaf V's Jubilee Foundation
- Maja and Hjalmar Leander Fund
- Royal Physiographic Society in Lund
Purpose: Epidemiologic studies indicate that dietary factors, such as coffee, may influence breast cancer and modulate hormone receptor status. The purpose of this translational study was to investigate how coffee may affect breast cancer growth in relation to estrogen receptor-alpha (ER) status. Experimental Design: The influence of coffee consumption on patient and tumor characteristics and disease-free survival was assessed in a population-based cohort of 1,090 patients with invasive primary breast cancer in Sweden. Cellular and molecular effects by the coffee constituents caffeine and caffeic acid were evaluated in ER+ (MCF-7) and ER- (MDA-MB-231) breast cancer cells. Results: Moderate (2-4 cups/day) to high (>= 5 cups/day) coffee intake was associated with smaller invasive primary tumors (P-trend = 0.013) and lower proportion of ER+ tumors (P-trend = 0.018), compared with patients with low consumption (<1 cup/day). Moderate to high consumption was associated with lower risk for breast cancer events in tamoxifen-treated patients with ER+ tumors (adjusted HR, 0.51; 95% confidence interval, 0.26-0.97). Caffeine and caffeic acid suppressed the growth of ER+ (P <= 0.01) and ER+ (P <= 0.03) cells. Caffeine significantly reduced ER and cyclin D1 abundance in ER+ cells. Caffeine also reduced the insulin-like growth factor-I receptor (IGFIR) and pAkt levels in both ER+ and ER- cells. Together, these effects resulted in impaired cell-cycle progression and enhanced cell death. Conclusions: The clinical and experimental findings demonstrate various anticancer properties of caffeine and caffeic acid against both ER+ and ER- breast cancer that may sensitize tumor cells to tamoxifen and reduce breast cancer growth. (C)2015 AACR.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据