期刊
TRENDS IN PARASITOLOGY
卷 32, 期 9, 页码 697-707出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.pt.2016.04.014
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资金
- NIAID NIH HHS [R01 AI103058] Funding Source: Medline
Phenotypic high-throughput screens are a valuable tool for identifying new chemical compounds with antimalarial activity. Traditionally, these screens have focused solely on the symptomatic asexual blood stage of the parasite life cycle; however, to discover new medicines for malaria treatment and prevention, robust screening technologies against other parasite life-cycle stages are required. This review highlights recent advances and progress toward phenotypic screening methodologies over the past several years, with a focus on exoerythrocytic stage screens.
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