期刊
TRENDS IN NEUROSCIENCES
卷 39, 期 5, 页码 311-324出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tins.2016.03.002
关键词
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资金
- Wellcome Trust PhD for Clinicians
- John and Lucille van Geest Foundation
- National Institute for Health Research, UK (NIHR)
- Acute Brain Injury and Repair theme of the Cambridge NIHR Biomedical Research Centre
- EU (CENTER-TBI) [602150]
- National Institute for Health Research [NF-SI-0512-10090] Funding Source: researchfish
Traumatic axonal injury (TAI) is an important pathoanatomical subgroup of traumatic brain injury (TBI) and a major driver of mortality and functional impairment. Experimental models have provided insights into the effects of mechanical deformation on the neuronal cytoskeleton and the subsequent processes that drive axonal injury. There is also increasing recognition that axonal or white matter loss may progress for years post-injury and represent one mechanistic framework for progressive neurodegeneration after TBI. Previous trials of novel therapies have failed to make an impact on clinical outcome, in both TBI in general and TAI in particular. Recent advances in understanding the cellular and molecular mechanisms of injury have the potential to translate into novel therapeutic targets.
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