期刊
TRENDS IN MOLECULAR MEDICINE
卷 22, 期 6, 页码 497-510出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.molmed.2016.04.007
关键词
-
资金
- European Commission (ERC-PHII)
- Ministero della Salute (Ricerca Finalizzata) [RF-2013-02355470]
- Cluster Alisei (MEDINTECH) [CTN01_00177_962865]
- Italian Cystic Fibrosis Research Foundation
- Italian Association for Cancer Research (AIRC)
The humoral arm of innate immunity is complex and includes various molecules that serve as markers of inflammation with complementary characteristics, such as the short pentraxins C-reactive protein (CRP) and serum amyloid P (SAP) and the long pentraxin PTX3. There is a growing amount of evidence - including mouse and human genetics - that suggests that PTX3 is essential in conferring host resistance against selected pathogens and, moreover, that it plays a dual antagonistic role in the regulation of inflammation. Dissection of such a yin-and-yang role of pentraxins in immunity and inflammation is timely and significant as it may pave the way for better clinical exploitation against various diseases.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据