期刊
TRENDS IN MOLECULAR MEDICINE
卷 22, 期 1, 页码 4-6出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.molmed.2015.11.009
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资金
- NIDDK NIH HHS [R01 DK076077, R01 DK087635, R01 DK105821, DP3 DK108220] Funding Source: Medline
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [DP3DK108220, R01DK105821, R01DK076077, R01DK087635] Funding Source: NIH RePORTER
Ten percent of the population worldwide suffers from chronic kidney disease (CKD), characterized by fibrotic changes in the kidney. Fibrosis is associated with loss of epithelial parenchyma, and accumulation of myofibroblasts, fibrillary collagen, and inflammatory cells. Two recent papers highlight the critical role of Twist and Snail transcription factors in kidney fibrosis.
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