期刊
TRENDS IN MICROBIOLOGY
卷 24, 期 6, 页码 490-502出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.tim.2016.03.003
关键词
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资金
- National Natural Science Foundation of China [81461168030]
- China National Grand S&T Special Project [2014ZX10004-001-006]
- National Key Program for Infectious Disease of China [2016ZX10004222]
- NSFC Innovative Research Group [81321063]
- Priority Academic Program Development of Jiangsu Higher Education Institution
- Banting Postdoctoral Fellowship from the Canadian Institutes of Health Research (CIHR)
- President's International Fellowship Initiative from the Chinese Academy of Sciences (CAS)
Human coronaviruses (HCoVs) were first described in the 1960s for patients with the common cold. Since then, more HCoVs have been discovered, including those that cause severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS), two pathogens that, upon infection, can cause fatal respiratory disease in humans. It was recently discovered that dromedary camels in Saudi Arabia harbor three different HCoV species, including a dominant MERS HCoV lineage that was responsible for the outbreaks in the Middle East and South Korea during 2015. In this review we aim to compare and contrast the different HCoVs with regard to epidemiology and pathogenesis, in addition to the virus evolution and recombination events which have, on occasion, resulted in outbreaks amongst humans.
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