期刊
TRENDS IN MICROBIOLOGY
卷 24, 期 5, 页码 345-355出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.tim.2016.01.006
关键词
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资金
- amfAR Research Consortium on HIV Eradication (ARCHE) [107857-48-RGRL, 108074-50-RGRL]
- Foundation for AIDS Research [108021-49-RFRL]
- Delaney AIDS Research Enterprise [U19 AI098109]
- Australian National Health and Medical Research Council [AAP1061681]
The introduction of antiretroviral therapy (ART) 20 years ago has dramatically reduced morbidity and mortality associated with HIV-1. Initially there was hope that ART would be curative, but it quickly became clear that even though ART was able to restore CD4(+) T cell counts and suppress viral loads below levels of detection, discontinuation of treatment resulted in a rapid rebound of infection. This is due to persistence of a small reservoir of latently infected cells with a long half-life, which necessitates life-long ART. Over the past few years, significant progress has been made in defining and characterizing the latent reservoir of HIV-1, and here we review how understanding the latent reservoir during suppressive therapy will lead to significant advances in curative approaches for HIV-1.
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