期刊
TRENDS IN IMMUNOLOGY
卷 37, 期 3, 页码 208-220出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.it.2016.01.004
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资金
- NCI NIH HHS [R01 CA177646, P30 CA010815, R01 CA100062, R01 CA084488, T32 CA009171] Funding Source: Medline
Myeloid-derived suppressor cells (MDSC) are one of the major components of the tumor microenvironment. The main feature of these cells is their potent immune suppressive activity. MDSC are generated in the bone marrow and, in tumor bearing hosts, migrate to peripheral lymphoid organs and the tumor to contribute to the formation of the tumor microenvironment. Recent findings have revealed differences in the function and fate of MDSC in the tumor and peripheral lymphoid organs. We review these findings here and, in this context, we discuss the current understanding as to the nature of these differences, the underlying mechanisms, and their potential impact on the regulation of tumor progression.
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