期刊
TRENDS IN IMMUNOLOGY
卷 37, 期 6, 页码 364-374出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.it.2016.03.009
关键词
-
类别
资金
- Else-Kroner-Fresenius-Stiftung (EKFS) [2013_A297]
- DFG [HO4281/2-1, TU 90/8-1, SFB 854 TP 27]
Phenotype switching contributes to nongenomic heterogeneity in melanoma and other cancers. These dynamic and in part reversible phenotype changes impose diagnostic and therapeutic challenges. Understanding the reciprocal coevolution of melanoma and immune cell phenotypes during disease progression and in response to therapy is a prerequisite to improve current treatment strategies. Here we discuss how proinflammatory signals promote melanoma cell plasticity and govern interactions of melanoma and immune cells in the tumor microenvironment. We examine phenotypic plasticity and heterogeneity in different melanoma mouse models with respect to their utility for translational research and emphasize the interplay between melanoma cells and neutrophils as a critical driver of metastasis.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据