期刊
TRENDS IN IMMUNOLOGY
卷 37, 期 11, 页码 724-737出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.it.2016.08.010
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资金
- NWO-TOP
- ERC
- NIH [RO1AI114495, RO1AI110374]
Since the discovery of MHC molecules, it has taken 40 years to arrive at a coherent picture of how MHC class I and MHC class II molecules really work. This is a story of the proteases and MHC-like chaperones that support the MHC class I and II molecules in presenting peptides to the immune system. We now understand that the MHC system shapes both the repertoire of presented peptides and the subsequent T cell response, with important implications ranging from transplant rejection to tumor immunotherapies. Here we present an illustrated review of the ins and outs of MHC class I and MHC class II antigen presentation.
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