期刊
TRENDS IN IMMUNOLOGY
卷 37, 期 8, 页码 557-568出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.it.2016.06.001
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类别
资金
- National Institutes of Health [Al049360, Al109962]
Accumulating studies demonstrate that IL-21 modulates the differentiation of various CD4 and CD8 T cell subsets and provide insights into the underlying cellular and molecular processes that are influenced by this cytokine. Intriguingly, the effects of IL-21 on T cells can be complex and vary depending on the experimental system used. We review our current understanding of the roles of IL-21 in the generation of phenotypically distinct CD4 and CD8 T cell populations and discuss the potential environmental cues, cellular factors, and molecular mediators that impact the actions of IL-21. We propose that IL-21 acts in a context-dependent manner to accentuate T cell subset development.
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