期刊
TRENDS IN IMMUNOLOGY
卷 37, 期 6, 页码 386-398出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.it.2016.04.003
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资金
- Wellcome Trust [108065/Z/15/Z, MR/M007367/1]
- UK Department for International Development
- Medical Research Council
- Bill and Melinda Gates Foundation [OPP1131320]
- MRC [MR/M007367/1] Funding Source: UKRI
- Medical Research Council [MR/M007367/1] Funding Source: researchfish
- Bill and Melinda Gates Foundation [OPP1131320] Funding Source: Bill and Melinda Gates Foundation
Malnutrition, which encompasses under- and overnutrition, is responsible for an enormous morbidity and mortality burden globally. Malnutrition results from disordered nutrient assimilation but is also characterized by recurrent infections and chronic inflammation, implying an underlying immune defect. Defects emerge before birth via modifications in the immunoepigenome of malnourished parents, and these may contribute to intergenerational cycles of malnutrition. This review summarizes key recent studies from experimental animals, in vitro models, and human cohorts, and proposes that immune dysfunction is both a cause and a consequence of malnutrition. Focusing on childhood undernutrition, we highlight gaps in current understanding of immune dysfunction in malnutrition, with a view to therapeutically targeting immune pathways as a novel means to reduce morbidity and mortality.
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